By what age does transient hypogammaglobulinemia of infancy usually resolve?

Transient hypogammaglobulinemia of infancy is a condition characterized by a temporary decrease in immunoglobulin levels, particularly immunoglobulin G (IgG). This condition is typically seen in infants and is considered a normal variation in the immune system's development. It tends to manifest around 2 to 3 months of age, as the maternal antibodies that infants acquire during pregnancy diminish over time.

The resolution of transient hypogammaglobulinemia usually occurs by the age of 2 to 4 years. By this age, the child's own immune system has matured sufficiently to produce adequate levels of immunoglobulins in response to infections and vaccines. It is crucial to monitor children for any recurrent infections during this period, as they may be more susceptible due to lower immunoglobulin levels, but most children resolve this condition without any long-term effects. Thus, understanding this timeline is important in pediatric care to differentiate transient conditions from more chronic immunodeficiency disorders.