Dysregulation of which eotaxin is linked to eosinophilic esophagitis?

Eosinophilic esophagitis (EoE) is an allergic inflammatory condition characterized by the presence of eosinophils in the esophagus, which leads to symptoms such as dysphagia and food impaction. The condition is associated with various inflammatory mediators, and eotaxins play a significant role in the recruitment of eosinophils to tissues.

Eotaxin-3, specifically, has been identified as a pivotal chemokine involved in the pathogenesis of eosinophilic esophagitis. Elevated levels of eotaxin-3 are frequently found in patients with EoE, and it appears to correlate with the severity of the disease and symptoms, suggesting that dysregulation of eotaxin-3 plays a significant role in the inflammatory response observed in EoE. It is instrumental in attracting eosinophils to the esophagus, which exacerbates the inflammation and contributes to the clinical manifestations of this condition.

In contrast, while the other eotaxins may play roles in various allergic responses and may be involved in other conditions, their direct link to eosinophilic esophagitis is less established in the literature, which centers on the role of eotax