How is mucociliary clearance evaluated clinically?

Mucociliary clearance is the process by which mucus traps inhaled particles and pathogens, and is then cleared from the airways through cilia movement. The saccharin test is a clinical evaluation specifically designed to assess the efficiency of mucociliary clearance in the respiratory system. During this test, a small amount of saccharin is placed in the nasopharynx, and the time it takes for the patient to taste the saccharin in their throat is measured. This method provides insight into the function of the mucociliary transport system; a delayed taste indicates impaired mucociliary clearance.

In contrast, other testing methods mentioned do not specifically evaluate mucociliary clearance. The sneeze test primarily assesses nasal function and reflexes, while the inhalation test and bronchial challenge test are more focused on airway responsiveness and bronchial reactivity, respectively. Thus, the saccharin test stands out as the most direct assessment of mucociliary function.