Hypogammaglobulinemia and thymoma are most closely associated with which condition in adults?

Hypogammaglobulinemia, which refers to low levels of immunoglobulins in the blood, and thymoma, a tumor originating from the thymus gland, are closely associated with Good’s syndrome. This condition is characterized by a combination of thymoma and hypogammaglobulinemia and is known to increase the risk of infections due to the associated immunodeficiency.

Good’s syndrome typically presents in adults, distinguishing it from conditions such as DiGeorge syndrome, which primarily affects children and is characterized by a developmental absence of the thymus and parathyroid glands. Severe combined immunodeficiency (SCID) is another immunodeficiency that usually appears in infancy and is not associated with thymoma. CHARGE syndrome is a genetic condition with a range of symptoms but does not specifically involve thymoma or hypogammaglobulinemia.

In summary, the association of hypogammaglobulinemia with thymoma points strongly to Good’s syndrome as the correct answer, as it is the only condition in adults known for this specific pairing of symptoms.