In the immune response, which cells are primarily involved in asthma pathophysiology?

Eosinophils play a crucial role in the pathophysiology of asthma, which is characterized by airway inflammation and hyperreactivity. In individuals with asthma, these cells are often found in elevated numbers within the airways and are involved in the inflammatory response associated with allergic triggers.

Eosinophils release a variety of mediators, including cytokines and lipid mediators, contributing to airway inflammation, tissue damage, and hyperresponsiveness. They are particularly important in allergic asthma, where their activation is often linked to IgE-mediated responses to allergens. This prompts a cascade of biological processes leading to airway constriction and increased mucus production, which are hallmark features of asthma.

Other immune cells, while they do play roles in the immune response, do not specifically contribute to asthma pathophysiology in the same way that eosinophils do. Neutrophils are more prominently involved in responses to bacterial infections and are not typically central to asthma. B cells are primarily responsible for antibody production, and while they can contribute to allergic responses through IgE production, they are not as directly involved in the inflammation seen in asthma as eosinophils. Antigen presenting cells are crucial for initiating immune responses but do not directly drive the chronic inflammation and