LTB4 can lead to chemotaxis of which cell types?

Leukotriene B4 (LTB4) is a potent inflammatory mediator that plays a significant role in the immune response, particularly in the recruitment and activation of various immune cells. It is well recognized for its strong chemotactic properties, which specifically influence the movement of cells toward sites of inflammation.

The primary cell types that respond to LTB4 through chemotaxis are neutrophils and eosinophils. Neutrophils are typically among the first responders to inflammatory sites, acting swiftly to address infections and tissue damage. Eosinophils, while often associated with allergic responses and parasitic infections, also react to LTB4 and migrate to sites of inflammation.

The mechanism involves LTB4 binding to specific receptors on these target cells, promoting their movement and enhancing their function in fighting infections or mediating allergic reactions. This chemotactic response is crucial for orchestrating an effective immune response, highlighting the importance of LTB4 in inflammation and allergy.

Understanding how LTB4 influences the movement of neutrophils and eosinophils underscores its role in various pathological conditions, including asthma, where these cells are key players in the inflammatory process. This makes it clear why this option is recognized as the correct answer regarding the effects