Patients with Wiskott-Aldrich syndrome are at increased risk for which condition?

Wiskott-Aldrich syndrome is a genetic disorder that affects the immune system, characterized by the triad of eczema, thrombocytopenia (low platelet count), and recurrent infections. A significant concern for individuals with Wiskott-Aldrich syndrome is their increased susceptibility to certain malignancies, particularly lymphomas. This susceptibility is primarily due to the dysfunction of T cells and the overall compromised immune system, which makes it difficult for the body to regulate abnormal cell growth.

Among the conditions listed, the association with EBV-related lymphoma is particularly strong. Patients with Wiskott-Aldrich syndrome have been shown to have a higher incidence of lymphoproliferative disorders, especially those associated with Epstein-Barr Virus (EBV). This virus can lead to the transformation of B cells and result in lymphomas, making it a notable risk for those with this syndrome.

The other conditions mentioned do not have the same level of established association with Wiskott-Aldrich syndrome. Sarcoidosis is an inflammatory condition that primarily affects the lungs and has no direct link to this genetic syndrome. Graft versus host disease typically occurs following allogeneic transplants, not as a consequence of Wiskott-Aldrich syndrome. Similarly, while patients