SNP variants in which cytokine are overexpressed in biopsy tissue of eosinophilic esophagitis?

The correct response is based on the role of various cytokines associated with eosinophilic esophagitis (EoE). EoE is characterized by an inflammatory response primarily driven by eosinophils, and specific cytokines have been identified as influencing this condition.

SNP (single nucleotide polymorphism) variants in the cytokine IL-13 are particularly notable in the context of EoE. IL-13 is a key mediator in allergic reactions and has been shown to be significantly involved in driving the eosinophilic infiltration seen in EoE. It plays a critical role in the upregulation of genes associated with tissue remodeling and eosinophil recruitment, contributing to the pathophysiology of the disease.

While other options like IL-4 and GM-CSF are also involved in immune responses and allergy, it is IL-13 that is specifically noted for its upregulation in patients with eosinophilic esophagitis based on biopsy study findings. Thus, understanding the functional role and expression of IL-13 provides insights into the mechanisms at play in EoE, making it the more relevant choice in this context.

Overall, the emphasis on SNP variants and the specific role of IL-13