Subepithelial deposits are found in which type of immune-mediated kidney disease?

Subepithelial deposits are characteristic of membranous nephropathy, which is an immune-mediated kidney disease. In this condition, immune complexes accumulate beneath the epithelial cells of the glomeruli, leading to a thickening of the glomerular capillary walls. This pathological change is primarily associated with the presence of antibodies against podocyte antigens, such as phospholipase A2 receptor.

Membranous nephropathy is characterized by a clinical presentation of nephrotic syndrome, with significant proteinuria, edema, and potential for progression to chronic kidney disease. The presence of these subepithelial immune complex deposits is a key finding when examining kidney biopsy specimens using techniques such as immunofluorescence microscopy.

The other conditions listed, such as minimal change disease, focal segmental glomerulosclerosis, and diabetic nephropathy, do not present with subepithelial deposits in the same manner or location. Minimal change disease, for instance, is characterized by effacement of podocyte foot processes rather than immune deposits. Focal segmental glomerulosclerosis typically manifests with hyaline deposits and scarring of segments of glomeruli, while diabetic nephropathy is characterized by distinct changes like mesangial expansion and thick