What antibody is associated with drug-induced lupus?

The antibody most commonly associated with drug-induced lupus is antihistone antibody. This type of antibody is often present in individuals who develop lupus-like symptoms as a result of certain medications. Drug-induced lupus is characterized by symptoms similar to systemic lupus erythematosus, but it typically resolves upon discontinuation of the offending drug.

Antihistone antibodies are a hallmark of drug-induced lupus, distinguishing it from idiopathic lupus. While other antibodies, such as anti-dsDNA, are more commonly linked to systemic lupus erythematosus and play a role in its pathogenesis, they are not specific to drug-induced forms of lupus. IgG4 antibodies are typically associated with other conditions, such as certain allergies or autoimmune pancreatitis, rather than lupus. Antiganglioside antibodies are primarily linked to neurological conditions, such as Guillain-Barré syndrome, and are not relevant to drug-induced lupus.

Thus, the presence of antihistone antibodies specifically points to the occurrence of drug-induced lupus, making it the correct answer in this context.