What are common triggers for attacks in patients with hyper-IgD syndrome (HIDS)?

Hyper-IgD syndrome (HIDS) is characterized by recurrent febrile attacks due to a genetic mutation that affects the immune system. Individuals with this condition often experience symptoms triggered by various environmental and physiological factors.

Stress and vaccinations are notable triggers for attacks in HIDS. Stress can provoke an inflammatory response in individuals with hyper-IgD syndrome, leading to the activation of the immune system and subsequent febrile episodes. Vaccinations may also incite an immune response that can result in an exacerbation of symptoms due to the underlying dysregulation of the immune system present in these patients.

While dietary changes, cold exposure, and physical exercise can influence health in general, they are not specifically recognized as primary triggers for attacks in hyper-IgD syndrome. Understanding the implications of stress and vaccinations on the immune response in HIDS is essential for managing potential flare-ups in these patients.