What are three main manifestations of Grave's disease?

Grave's disease is an autoimmune disorder that primarily results in hyperthyroidism, which is characterized by an overproduction of thyroid hormones. This condition leads to a range of symptoms related to increased metabolic activity. The three main manifestations associated with Grave's disease include hyperthyroidism itself, which can cause increased heart rate, weight loss, and nervousness; exophthalmos, which refers to the bulging of the eyes due to inflammation and swelling of the tissues behind the eye; and pretibial myxedema, a skin condition where there is thickening and swelling of the skin, particularly over the shins.

These manifestations are specific to Grave's disease and distinguish it from other thyroid conditions. Hyperthyroidism is the underlying metabolic disorder, while exophthalmos and pretibial myxedema are classical signs associated with the autoimmune nature of the disease, reflecting the effects of the immune response on various tissues in the body. The other options refer to conditions that do not align with the typical presentations of Grave's disease or describe symptoms of other thyroid dysfunctions or unrelated issues.