What complement factors will inhibit the formation of immune complexes?

Prepare for the ACAAI Board Exam. Utilize flashcards and comprehensive multiple-choice questions, equipped with hints and detailed explanations. Ace your allergy and clinical immunology exam efficiently.

The option that indicates the correct factors involved in inhibiting the formation of immune complexes is Factor H and Factor I. These complement factors play a crucial role in regulating the complement system, particularly in the context of preventing excessive complement activation that could lead to the formation of immune complexes.

Factor H is a control protein that helps to prevent the activation of the alternative pathway of the complement system by binding to C3b, displacing Bb, and allowing for the degradation of C3b, thereby limiting the generation of C3 convertase and reducing complement activation. Factor I, on the other hand, acts by cleaving C3b when in complex with Factor H, further contributing to the regulation of complement activity.

By effectively controlling C3b levels and preventing the amplification of the complement cascade, Factor H and Factor I help to inhibit the excessive formation of immune complexes, which are often implicated in various autoimmune and inflammatory diseases.

The other options mention factors that do not play a significant role in the inhibition of immune complex formation. Factors B and D are involved more in the activation of the complement pathways, while Factors A and F do not have a direct inhibitory function on immune complexes. Understanding the roles of these complement factors is essential for grasping how the body regulates

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