What does the CD88 receptor bind to?

The CD88 receptor is a well-studied member of the G protein-coupled receptor family and primarily binds to C5a, which is an anaphylatoxin generated during the complement activation cascade. When complement proteins are activated, they lead to the generation of C5a, which plays a significant role in promoting inflammation by attracting immune cells to sites of injury or infection. The interaction of C5a with CD88 on various immune cells, such as neutrophils and monocytes, triggers a variety of pro-inflammatory responses, including enhanced phagocytic activity, degranulation, and the release of additional inflammatory mediators.

Other options present substances that are relevant in immune responses, but they do not bind to the CD88 receptor. Histamine is released from mast cells and basophils and acts primarily through its own receptors, while leukotrienes are lipid mediators derived from arachidonic acid that operate through specific cysteinyl leukotriene receptors. IgE is an immunoglobulin involved in allergic reactions and binds to Fc receptors on mast cells and basophils but does not interact with CD88. Thus, the correct binding partner for the CD88 receptor is indeed the C5a anaphylatoxin.