What immunoglobulin-like lectin is uniquely found on human eosinophils?

SIGLEC-8 is the immunoglobulin-like lectin that is uniquely expressed on human eosinophils. This surface marker plays a significant role in recognizing and binding to specific sialic acid-containing glycoconjugates, which are often present on the surfaces of pathogens and other cells. The engagement of SIGLEC-8 can influence eosinophil functions, including survival, activation, and apoptosis, thereby playing a role in regulating immune responses, particularly in allergic conditions and asthma.

Understanding the significance of SIGLEC-8 in eosinophil biology is crucial because it highlights how these cells participate in immune regulation and can contribute to the pathophysiology of allergic diseases and other eosinophil-related disorders. The presence of this marker allows for the differentiation of eosinophils from other leukocytes, enhancing our understanding of their specific roles in immune responses.