What is a common complication of IVIG therapy?

The common complication of intravenous immunoglobulin (IVIG) therapy is renal failure, particularly due to the potential for acute kidney injury associated with certain formulations of IVIG. Factors contributing to this risk include the osmotic load of the product and the occurrence of hyperviscosity, which can lead to renal impairment.

Although there are potential risks for anaphylaxis, thrombosis, and gastrointestinal bleeding associated with IVIG therapy, renal failure is specifically noted as a significant complication. IVIG can affect renal function by inducing changes in renal hemodynamics or triggering an inflammatory response, especially in patients who are already predisposed to renal issues. Monitoring renal function is essential in patients receiving IVIG, particularly those with risk factors for kidney disease, to mitigate this serious complication.