What is the minimum tryptase level considered significant in cases of anaphylaxis?

In cases of anaphylaxis, a tryptase level of 11 ng/mL is considered significant. Tryptase is a protein released primarily by mast cells during allergic reactions, and its measurement can aid in the diagnosis of anaphylaxis. Elevated tryptase levels typically indicate mast cell activation and correlate with the severity of the reaction.

In clinical practice, a tryptase level above 11 ng/mL is significant because it demonstrates a clear elevation that is consistent with mast cell degranulation commonly seen during anaphylactic events. Levels above this threshold support the hypothesis of anaphylaxis as the cause of the clinical symptoms observed. Consequently, monitoring tryptase levels is an important diagnostic tool in confirming anaphylaxis or understanding the mast cell involvement in various allergic reactions.