What is the treatment of choice for poststreptococcal glomerulonephritis?

Poststreptococcal glomerulonephritis (PSGN) is a complication that can arise after an infection with certain strains of Streptococcus bacteria, often following a throat or skin infection. Once a patient develops PSGN, the focus of treatment is primarily supportive, as the condition generally has a self-limiting course.

Supportive therapy may include measures to manage hypertension, fluid retention, and other symptoms, depending on the severity of the condition. This can involve monitoring kidney function, managing dietary restrictions, and sometimes diuretics to control edema. Most patients recover fully without the need for more aggressive treatments.

While antibiotics may be prescribed if there is an active streptococcal infection to prevent further complications, they do not have a direct therapeutic effect on PSGN itself since the glomerular damage has already occurred due to the previous infection. Corticosteroids and immunosuppressants are typically not indicated in PSGN, as they are more relevant for other renal conditions characterized by immune-mediated injury, such as nephrotic syndrome or certain types of glomerulonephritis. Thus, the cornerstone of PSGN management remains supportive care, allowing for natural recovery and minimizing complications.