What primary immunodeficiencies are associated with high IgE levels?

High levels of Immunoglobulin E (IgE) are primarily associated with certain immunodeficiencies, notably Hyper-IgE syndrome and Wiskott-Aldrich syndrome.

Hyper-IgE syndrome, also known as Job's syndrome, is characterized by recurrent skin and lung infections, along with markedly elevated serum IgE levels. This condition results from defects in the immune system, particularly in the pathways that regulate IgE production, leading to an inability to effectively respond to infections and increased allergenic responses.

Wiskott-Aldrich syndrome, while primarily known for its triad of eczema, thrombocytopenia, and recurrent infections, also demonstrates elevated IgE levels. The defect lies within the immune system, specifically affecting B cells and T cells. Patients often present with immunological issues that lead to increased susceptibility to infections and allergic reactions, contributing to elevated IgE.

Other listed conditions do not typically present with high IgE levels. For instance, AIDS is more associated with low levels of immunoglobulins due to the destruction of CD4+ T cells. Chronic Granulomatous Disease involves dysfunction in phagocytic cells, but does not inherently increase IgE levels. Cystic Fibrosis primarily affects the respiratory