What role do CD18 and CD15s play in leukocyte function?

CD18 and CD15s play crucial roles in lymphocyte adhesion and migration, which are essential processes in the immune response. CD18 is a part of the integrin family and is necessary for leukocyte adhesion to endothelial cells, which allows them to exit the bloodstream and migrate to sites of inflammation or infection. It pairs with CD11 to form the LFA-1 (leukocyte function-associated antigen-1), facilitating the strong adhesion of leukocytes to the vascular endothelium during an immune response.

CD15s, on the other hand, are carbohydrates that are present on the surface of certain leukocytes and play a significant role in mediating interactions between leukocytes and endothelial cells, enhancing the process of migration and adhesive interactions.

By supporting the attachment and movement of white blood cells, CD18 and CD15s are vital for their proper function during immune surveillance and response, making the option regarding cell adhesion and migration the correct one.