What triad is classic in Wiskott-Aldrich syndrome?

The classic triad associated with Wiskott-Aldrich syndrome includes thrombocytopenia, eczema, and recurrent infections. Understanding these components is essential.

Thrombocytopenia refers to a low platelet count, which is a hallmark of this syndrome and can lead to an increased risk of bleeding and bruising.

Eczema, or atopic dermatitis, is a chronic skin condition that is also a prominent feature of Wiskott-Aldrich syndrome. It typically presents in childhood and can be quite severe.

Recurrent infections occur due to the immunodeficiency associated with the syndrome. Individuals often have defects in both humoral and cellular immunity, leading to a greater susceptibility to infections, particularly by encapsulated bacteria.

This triad is significant because it highlights the unique combo of symptoms that helps in diagnosing Wiskott-Aldrich syndrome, linking hematologic, dermatologic, and immunologic abnormalities. The other options describe different conditions or symptom combinations not characteristically associated with Wiskott-Aldrich syndrome.