What type of agents are most commonly responsible for occupational asthma in developed nations?

Occupational asthma in developed nations is often caused by both high molecular weight (HMW) and low molecular weight (LMW) agents. HMW agents are typically proteins from sources such as animal dander, latex, and certain plants, which elicit an immune response leading to asthma in sensitized individuals. LMW agents, on the other hand, tend to be small chemical compounds that can induce asthma through direct irritative effects or by causing sensitization in some individuals.

The combination of both types of agents is significant, as they can interact in complex ways and may affect a broader range of the workforce. The presence of both HMW and LMW agents highlights the diverse environments found in occupational settings that may lead to asthma, making it essential to recognize both types when assessing potential triggers for occupational asthma. Therefore, acknowledging the role of both high and low molecular weight agents provides a more comprehensive understanding of the etiology of asthma related to occupational exposure.