What type of ANCA antibody is commonly found in granulomatosis with polyangiitis?

Granulomatosis with polyangiitis, formerly known as Wegener's granulomatosis, is primarily associated with the presence of c-ANCA antibodies. These antibodies are directed against proteinase 3 (PR3), which is a neutrophil granule protein. The presence of c-ANCA is significant in diagnosing this condition, as it helps differentiate it from other forms of vasculitis.

In clinical practice, detecting c-ANCA is usually accompanied by a clinical picture of respiratory tract involvement, renal implications, and systemic symptoms, which are hallmark features of granulomatosis with polyangiitis. This association reinforces the critical role of c-ANCA as a serological marker in confirming the diagnosis and guiding treatment decisions.