What type of mast cells are typically found in the skin and have the CD88 receptor?

Mast cells play a critical role in the immune system, particularly in allergic reactions and responses to various pathogens. The type of mast cells that are typically found in the skin are known as connective tissue mast cells (MCTC). These cells are characterized by the presence of various surface receptors that influence their behavior and function. Among the key receptors found on connective tissue mast cells is the CD88 receptor, which is a marker for a specific type of signaling related to immune responses mediated by complement.

The abundance of MCTC in the skin and their functional characteristics, including the presence of CD88, make them particularly significant in the context of cutaneous allergic responses and other skin-related immune activities. In contrast, mucosal mast cells (MMC) are primarily located in mucosal tissues and differ in their receptor repertoire and role in the immune system. Basophils and neutrophils, while important components of the immune response, do not share the same structural and functional characteristics as mast cells. Thus, the identification of connective tissue mast cells as the type that expresses the CD88 receptor emphasizes their distinct role and presence in the skin.