Which chemokine has a strong association with the development of eosinophilic esophagitis?

Prepare for the ACAAI Board Exam. Utilize flashcards and comprehensive multiple-choice questions, equipped with hints and detailed explanations. Ace your allergy and clinical immunology exam efficiently.

Eotaxin-3 is a key chemokine involved in the recruitment of eosinophils to various tissues, particularly in conditions associated with allergic responses and chronic inflammation, such as eosinophilic esophagitis (EoE). EoE is characterized by an accumulation of eosinophils in the esophagus, often in response to certain allergens, and Eotaxin-3 is particularly effective at attracting these cells due to its high affinity for the CCR3 receptor expressed on eosinophils.

The role of Eotaxin-3 in eosinophilic esophagitis has been highlighted in studies showing that levels of this chemokine correlate with the severity of the condition and contribute significantly to the inflammatory process in the esophagus. Eotaxin-3's specific involvement in this pathway makes it a critical factor in understanding the immunological underpinnings of eosinophilic esophagitis, supporting its association with disease development.

Other chemokines may play roles in allergic inflammation, but Eotaxin-3 stands out as the most significant in the context of eosinophilic esophagitis due to its direct role in the recruitment of eosinophils specifically

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