Which component is common to both IL-4 and IL-13 receptors?

The component that is common to both IL-4 and IL-13 receptors is IL-4 Rα. This subunit is a crucial part of the receptor complexes for both interleukins, enabling the signaling pathways that lead to various immune responses, such as B-cell differentiation, IgE production, and mucosal inflammation.

Both IL-4 and IL-13 are cytokines that play significant roles in the immune system, particularly in the context of allergic responses and asthma. They can share pathways through the common use of IL-4 Rα. This overlap is critical in terms of understanding therapeutic targets for diseases driven by these cytokines, such as allergic rhinitis and asthma.

In contrast, while the other options might be important in their own specific contexts or other signaling pathways, they do not serve as common receptors for both IL-4 and IL-13. For instance, IL-2 Rβ is primarily involved in the signaling of interleukin-2, and IL-5 Rα is specific to IL-5 signaling. IL-13 Rα1, while connected to IL-13 signaling, is not shared with IL-4, which underscores the specificity of these receptor interactions. Thus, IL-4 Rα is indeed