Which cytokine is primarily associated with pruritus in atopic dermatitis?

The primary cytokine associated with pruritus in atopic dermatitis is IL-31. This cytokine is a product of T-helper 2 (Th2) cells and has been shown to play a significant role in the sensation of itch. IL-31 acts on neurons involved in the itch pathway, leading to the manifestation of pruritus, which is one of the hallmark symptoms of atopic dermatitis.

Research indicates that elevated levels of IL-31 are found in the skin and serum of individuals with atopic dermatitis, correlating with the severity of itch experienced by patients. This makes IL-31 crucial for understanding the pathophysiology of pruritus in this condition.

Other cytokines mentioned, while they have roles in the inflammatory response associated with atopic dermatitis, do not have the same direct connection to inducing itch. For example, IL-4 has a role in promoting the Th2 response and can influence other aspects of dermatitis, but it is not the primary driver of itch. Similarly, IL-6 and IL-10 are involved in immune regulation and inflammation but do not directly mediate pruritus in atopic dermatitis like IL-31 does.