Which gene translocation is commonly seen in Burkitt's lymphoma?

Burkitt's lymphoma is characterized by a specific chromosomal translocation involving the c-myc gene, which plays a crucial role in cell cycle regulation and apoptosis. The most common translocation associated with Burkitt's lymphoma is t(8;14), where the c-myc gene on chromosome 8 is translocated to chromosome 14, juxtaposing it next to the immunoglobulin heavy chain locus. This aberration leads to overexpression of the c-myc protein, promoting increased cell proliferation.

This mechanism is fundamental in understanding the pathophysiology of Burkitt's lymphoma, as the deregulation of c-myc results in uncontrolled cellular growth, a hallmark of cancer. The translocation not only highlights the genetic changes associated with the disease but also serves as a diagnostic marker, guiding diagnosis and potential treatment strategies in a clinical setting. The prominence of c-myc in this context emphasizes its significance in the oncogenesis of Burkitt's lymphoma.