Which leukotrienes are measured by ELISA?

The measurement of leukotrienes in clinical settings is essential for understanding inflammatory conditions, particularly asthma and allergic responses. When using Enzyme-Linked Immunosorbent Assay (ELISA), the specific leukotrienes that are typically quantified include LTC4, LTD4, and LTE4.

These leukotrienes are part of a group of lipid mediators known for their role in bronchoconstriction, vascular permeability, and other aspects of the inflammatory process. The identification and quantification of these specific leukotrienes provide valuable insights into the pathophysiology of conditions involving airway inflammation and hyperreactivity.

LTC4, LTD4, and LTE4 are synthesized from arachidonic acid and are part of the cysteinyl leukotriene family, which are particularly significant in mediating allergic and asthmatic reactions. These specific leukotrienes are commonly measured together in assays due to their interrelated functions and the cumulative impact they have on respiratory health.

Other options presented in your choices do not capture the full spectrum of leukotrienes effectively measured by ELISA, which is why the correct choice focuses on the inclusion of all three: LTC4, LTD4, and LTE4.