Which mitogens are known to stimulate T cells?

The selection of pokeweed, phytohemagglutinin, and concanavalin A as mitogens that stimulate T cells is grounded in their well-established roles in immunology. Each of these substances has been shown to induce T cell proliferation and activation.

Pokeweed mitogen is derived from the pokeweed plant and is known for its ability to stimulate lymphocyte proliferation, particularly effective in stimulating T cells. Phytohemagglutinin (PHA) is a potent plant lectin that specifically activates T cells by cross-linking surface glycoproteins, leading to cell division. Concanavalin A (Con A), another plant lectin, is also capable of inducing T cell activation through similar mechanisms.

Collectively, these agents provide a robust means for investigating T cell responses in vitro, as they effectively promote cell division and activation in T cell populations. Hence, this combination accurately represents mitogens that specifically stimulate T cells, making it the best choice among the available options.