Which of the following is a characteristic of granulomatous-lymphocytic interstitial lung disease (GLILD)?

Granulomatous-lymphocytic interstitial lung disease (GLILD) is characterized by the presence of lymphocytic infiltration and granulomatous inflammation in the lung interstitium, which often leads to the development of pulmonary nodules. These nodules can vary in size but are frequently larger compared to those seen in other forms of interstitial lung diseases. This characteristic is significant as it helps distinguish GLILD from conditions that may present with different patterns of nodules or lung infiltrates.

The other choices do not align with the typical characteristics of GLILD. For instance, GLILD does not always present with fever; while some patients may experience systemic symptoms, this is not a hallmark feature. Additionally, it does not exclusively affect middle-aged males, as it can occur in individuals of different ages and genders. Similarly, pleural effusions are not primarily associated with GLILD, as the condition is more characterized by parenchymal lung involvement rather than significant pleural disease. This underscores the importance of recognizing the unique features of GLILD within the spectrum of interstitial lung diseases.