Which primary immunodeficiency disorder is characterized by recurrent infections without abscess formation?

Leukocyte Adhesion Deficiency (LAD) is characterized by recurrent infections that occur without abscess formation due to the incapacity of white blood cells to adhere to the endothelium and migrate to sites of infection. In this condition, leukocytes (particularly neutrophils) are unable to exit the bloodstream and effectively navigate to tissues to combat pathogens, leading to an increased risk of infections. However, because they are unable to properly infiltrate tissues, patients typically do not develop abscesses, which often require the accumulation of neutrophils at the infection site, resulting in pus formation.

The other disorders mentioned tend to present with different clinical features. For instance, in Chronic Granulomatous Disease, patients do experience infections, but these are often associated with the formation of granulomas and may present with abscesses due to the inability of neutrophils to fully eliminate certain catalase-positive organisms. Wiskott-Aldrich Syndrome involves a triad of symptoms: eczema, thrombocytopenia, and immune deficiency, but does not specifically present with recurrent infections without abscess formation. Common Variable Immunodeficiency also leads to recurrent infections, but the pattern tends to be broader and does not specifically exclude the possibility of abscess formation