Which type of systemic mastocytosis is associated with cytopenias and liver injury?

Systemic mastocytosis with associated cytopenias and liver injury is characteristic of systemic mastocytosis with an associated hematologic neoplasm. This condition involves the proliferation of mast cells in tissues, leading to various symptoms and complications. In particular, the presence of an associated hematologic neoplasm, such as acute myeloid leukemia or other myeloproliferative disorders, can result in complications like cytopenias due to bone marrow infiltration and disruption of normal hematopoiesis, as well as liver injury due to increased mast cell burden leading to changes in liver architecture and function.

The other types of systemic mastocytosis do not typically present with these complications. Indolent systemic mastocytosis usually has a more benign course with fewer systemic symptoms, and localized mast cell tumors refer to specific lesions rather than systemic disease. While aggressive systemic mastocytosis can have severe manifestations, the specific combination of cytopenias and liver injury is more accurately described with systemic mastocytosis associated with a hematologic neoplasm. This distinction is crucial for diagnosis and management strategies.