Which vaccine is contraindicated in individuals with severe atopic dermatitis?

The vaccine that is contraindicated in individuals with severe atopic dermatitis is the smallpox vaccine. This is primarily due to the fact that the smallpox vaccine contains live vaccinia virus, which can lead to complications in individuals with skin conditions like atopic dermatitis. These individuals may have compromised skin barriers, increasing the risk of vaccine-related adverse effects, particularly the risk of widespread vaccine infection on the compromised skin.

In contrast, the other vaccines listed—mumps, influenza, and measles—do not pose a similar level of risk for those with atopic dermatitis and are generally considered safe for administration to these patients. Therefore, the smallpox vaccine is singled out for its specific risks associated with the dermatological condition, highlighting the importance of careful evaluation of the patient's history and health status before administering live vaccines.